Graft-versus-host disease (GvHD) is a significant complication of allogeneic hematopoietic
stem cell transplantation. In order to develop new therapeutic approaches, there is a need to
recapitulate GvHD effects in preclinical, in vivo systems, such as mouse and humanized
mouse models. In humanized mouse models of GvHD, mice are reconstituted with human
immune cells, which become activated by xenogeneic (xeno) stimuli, causing a multi-system
disorder known as xenoGvHD. Testing the ability of new therapies to prevent or delay the …